11 August 2012

Cann JA, Jahrling PB, Hensley LE, Wahl-Jensen V. Comparative pathology of smallpox and monkeypox in man and macaques. J Comp Pathol. 2013 Jan;148(1):6-21. PubMed: https://pubmed.gov/22884034. Full text: https://doi.org/10.1016/j.jcpa.2012.06.007

The paper provides a contemporary review (2012) of smallpox, as well as discussion of how it compares with human monkeypox and the corresponding diseases in macaques.

 

18 January 2007

Stanford MM, McFadden G, Karupiah G, Chaudhri G. Immunopathogenesis of poxvirus infections: forecasting the impending storm. Immunol Cell Biol. 2007 Feb-Mar;85(2):93-102. PubMed: https://pubmed.gov/17228320. Full text: https://doi.org/10.1038/sj.icb.7100033

“The elegant dance played between the immune system of the host and the immunomodulatory proteins of poxviruses is an excellent example of the evolutionary co-dependence of pathogen and host. The host has evolved complex defense mechanisms to keep the destructive nature of invading microorganisms at bay and to clear them effectively while protecting against further attack. As a counterpoint, pathogens are constantly under pressure to evade the immune response of their host and, poxviruses in particular, actively manipulate the host immune system to survive and replicate.”